Carnosine - Anti-ageing
Carnosine has so many youthful benefits it almost
seems difficult to see how one simple dipeptide can have such a tremendous effect
on rejuvenating the body. Carnosine has an outstanding ability to rejuvenate old
cells (senescence cells) into healthy cells. It has always been thought that old
cells could not be rejuvenated until carnosine was studied.
appears that most cells can only divide so many times, but the higher the carnosine
levels the more times cells can divide. Therefore, the healthier we can keep the
cells by keeping older cells from aging as fast, the longer the time between cell
divisions, the longer life can be.
Carnosine extends cultured human fibroblast
life-span, kills transformed cells, protects cells against aldehydes, against
an ß-amyloid peptide fragment (characteristic in Alzheimer´s disease),
and against alpha-Synuclein produced in Parkinson´s disease, and it inhibits,
at least in vitro (in the test tube), protein glycation and DNA/protein cross-linking.
In a recent article, Dr Marios Kyriazis reported that his patients who
take carnosine supplements often receive comments that they simply look younger.
This may be a reflection of the phenomenon observed in 'in vitro' experiments
which show that carnosine actually rejuvenates older cells in culture (Hipkiss
2002), and 'in vivo' animal experiments in which carnosine prevented the development
of visible features of aging.
In that study, carnosine significantly delayed
the appearance of skin ulcers, periopthalmic lesions, spinal lordokyphosis and
behavioral responses of aged animals. In another recent article, Russian scientists
reported that not only did the carnosine-fed mice appear much more youthful than
controls, but experienced a 20% increase in lifespan.
And rumours have
it that Boris Yeltsin (the Russian ex-president) has been on the "Russian
supervitamin", i.e., carnosine, for some time, as he now looks ten years
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