Carnosine - Muscle ageing, muscle disorders
When
man ages from 20 to 70 years of age, the lean body mass (muscles) decline by 20
%, and muscular strength and endurance decline likewise. The carnosine concentration
and the antioxidant effect of carnosine decreases by half as age increases. This
marked reduction in muscle carnosine concentration may be a cause of the age-related
decline in muscle mass, strength and endurance. The active, strong so-called
fast muscle fibres contain much carnosine, while weak and atrophied fibres contain
little. The Russian scientist Severin observed already in the 1950´s that
addition carnosine to the liquid where exhausted isolated from muscle was incubated,
immediately restored the full muscle energy. The Australian tea, led by Dr MacFarlane,
has recently shown that supplementation with carnosine increases the strength
and endurance of tired muscles. The more you take carnosine, the higher is the
content in your muscles. Carnosine has a role in the following neuromuscular
disorders, too: - ALS (amyotrophic lateral sclerosis)
- Duchenne´s
muscle dystrophy
- myastenia gravis (MG),
- polymyositis
- medicine-related
muscle diseases (e.g., statins)
- late-onset-mitochondrial myopathy.
The
role of carnosine in neuromuscular diseases has been investigated scientifically,
and the results suggest supplementation with carnosine. While carnosine does not
cure these grave disorders, it halts the oxidative stress and may increase the
contractility of the muscles and add some strength and endurance.
Patients
with Duchenne´s dystrophy have only half of the normal carnosine content
in their muscles. Therefor it seems pertinent to recommend carnosine as a supplement.
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